Paparazzi photos from Wednesday, April 21

Jessica Simpson leaving her hotel in Manhattan (pics start here)

Conan O'Brien out and about in Brentwood (pics start here)

Charlize Theron arriving to the Staples Center in L.A. (pics start here)

Josh Duhamel riding his bike in Brentwood (pics start here)

Julia Louis-Dreyfus out and about in Brentwood (pics start here)

Adam Sandler on the set of Just Go With It in Maui (pics start here)

Helena Christensen eating lunch in New York (pics start here)

AnnaLynne McCord shopping at Ralphs in Beverly Hills (pics start here)

Leona Lewis leaving the Newsroom Cafe in West Hollywood (pics start here)

Nicky Hilton leaving Coffee Bean & Tea Leaf in West Hollywood (pics start here)

Demi Moore arriving to the Ed Sullivan Theater in New York (pics start here)

Selma Blair leaving Coffee Bean & Tea Leaf in Studio City (pics start here)

Heidi Klum leaving the Hollywood Foreign Press building in L.A. (pics start here)

Pamela Anderson arriving to the Staples Center in L.A. (pics start here)

Chris O'Donnell on the set of NCIS: Los Angeles in downtown L.A. (pics here)

*158 pics total in the gallery:

[Flynet, WENN, Pacific Coast News, Mavrixonline]