Yup, it's official. From CNN:

Reality TV star and former model Anna Nicole Smith was pronounced dead Thursday after being taken to a Florida hospital after being found unconscious in her hotel room, a law enforcement source with knowledge of the case told CNN.

Smith's private nurse called hotel workers at 1:38 p.m. and security officials went to the room, Seminole Police Chief Charlie Tiger said. Before rescue workers arrived, Smith's bodyguard performed CPR on her, he said. She was taken to Memorial Regional Hospital in Hollywood at 2:10 p.m. where she died. (Source)

In a statement Thursday, Anna's sister, Donna Hogan, said:

"We are saddened and heartbroken by my sister's death. No matter what our differences have been over the years, Anna was still our blood and she will be missed terribly. She was a woman who was determined to get out of her small town in Texas and make a name for herself."

y pick of Dakota Fanning in the 2007 Celebrity Death Pool is suddenly not looking so good.

UPDATE: Enough with the hate emails. My ticket to hell has been punched for quite some time thank-you.

UPDATE II: Added some pictures of Anna at a Vegas Trimspa appearance after the jump...